730 Modelling altered cell proliferation and differentiation in psoriasis
نویسندگان
چکیده
Psoriasis is a chronic inflammatory disease characterized by immune cytokine-stimulated epidermal hyperproliferation. The epidermis breaks from non-lesional (healthy) state to new steady with higher ratio of each cell type. During this process, T derived cytokines not only cause an increase in proliferation but also alter how these cells divide. We developed agent-based model understand psoriasis alters stem and TA division. Three types division modelled were self (i.e. 2 daughter same type as parent), symmetric different parent) asymmetric 1 another the specific probability occurring. has three states - normal, expanding (transition psoriasis) balanced lesional (psoriatic) skin. state, hyperproliferation occurs until targeted number, approximately 3-5 times more than skin, reached switches obtain homeostasis. used similar concept wound healing stages when first triggered obtaining Parameter scans ranging 0.1-0.4 (in 0.05 steps) 0.075-0.425 0.025 for respectively. results obtained showed probabilities differed In cells, producing changed 0.1 ∼0.25. While differentiated 0.07 ∼0.375 state. rate at least one significantly. validated proliferative behavior described literature. addition, our provided detailed insights about or other diseases develop generated testable hypotheses lineage development vivo.
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2023
ISSN: ['1523-1747', '0022-202X']
DOI: https://doi.org/10.1016/j.jid.2023.03.739